The phagocytosis of plumonary alveolar macrophage in patients with plumonary alveolar proteinosis.
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چکیده
منابع مشابه
Alveolar Macrophage Phagocytosis of NTHI
Background. Interactions of nontypeable Haemophilus influenzae (NTHI) with human alveolar macrophages are implicated in the persistence of NTHI in chronic obstructive pulmonary disease (COPD). However, the immunologic mechanisms that mediate NTHI-induced macrophage responses are poorly understood. We hypothesized that immunologic responses of alveolar macrophages to NTHI are impaired in COPD. M...
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I N a now classic article, Rosen and associates1 described an alveolar filling disease which they named pulmonary alveolar proteinosis. This disorder is of unknown origin and usually occurs as a primary process, although it may also be seen in association with hematologic neoplasms.2 In alveolar proteinosis the distal air spaces become filled with a lipoproteinaceous material that has chemical ...
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Alveolar proteinosis (AP) is characterized by excessive surfactant accumulation, and most cases are of unknown etiology. Standard therapy for AP is whole-lung lavage, which may not correct the underlying defect. Because the hematopoietic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for normal surfactant homeostasis, we evaluated the therapeutic activity of GM-C...
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RATIONALE Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activat...
متن کاملPulmonary Alveolar Proteinosis
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 1989
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.12.162